• Test Code:
    2040
  • Department:
    Molecular Genetics
  • Test Synonyms:
    Homocysteine, DNA Test • Methylene Tetrahydrofolate Reductase • MTHFR (C677T)
  • CPT Code(s):
Background:

In an effort to provide the most up-to-date test menu, KDL will no longer offer MTHFR genotyping.

The American College of Medical Genetics has a published Practice Guideline on MTHFR (see: https://www.acmg.net/docs/MTHFR_gim2012165a_Feb2013.pdf).

ACMG Recommendations Summarized:

  • MTHFR polymorphism genotyping should not be ordered as part of the clinical evaluation for thrombophilia or recurrent pregnancy loss.
  • MTHFR polymorphism genotyping should not be ordered for at-risk family members
  • MTHFR status does not change the recommendation that women of childbearing age should take the standard dose of folic acid supplementation.

We value your continued support of Knight Diagnostic Laboratories. If you have any questions, please do not hesitate to call. 

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The Knight Cancer Institute at Oregon Health & Science University is a pioneer in the field of precision cancer medicine. The institute's director, Brian Druker, M.D., helped prove it was possible to shut down just the cells that enable cancer to grow. This breakthrough has made once-fatal forms of the disease manageable and transformed how cancer is treated. The OHSU Knight Cancer Institute is the only National Cancer Institute-designated Cancer Center between Sacramento and Seattle – an honor earned only by the nation's top cancer centers. It is headquarters for one of the National Cancer Institute's largest research collaboratives, SWOG, in addition to offering the latest treatments and technologies as well as hundreds of research studies and clinical trials.

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