Translational research is the foundation for the testing performed at the Knight Diagnostic Laboratories, which serve as a pillar in the Knight Cancer Institute’s strategy to continue to lead the field of personalized cancer medicine. The laboratories are committed to the adoption of the latest technologies in order to provide the highest quality and most cost-effective testing services to meet clinical needs. Close association with clinicians and researchers in the OHSU Knight Cancer Institute make the Knight Diagnostic Laboratories (KDL) a productive partner for researchers, companion diagnostics and clinical trial test development.

During the past decade healthcare has witnessed a revolution in DNA sequencing technologies. These advances have fueled major discoveries in our understanding of molecular genetics and cancer. With support from the Knight Cancer Institute, KDL was among the first in the country to adopt next-generation sequencing (NGS) for clinical use. KDL has since gone on to develop its GeneTrails® series of NGS panels that are customized for the analysis of hematologic malignancies and solid tumors at both the DNA and RNA level. In addition, KDL works with biotechnology companies in piloting new approaches to the evaluation of gene methylation as well as proteomic-based analyses of tumor states. 


The Knight Cancer Institute at Oregon Health & Science University is a pioneer in the field of precision cancer medicine. The institute's director, Brian Druker, M.D., helped prove it was possible to shut down just the cells that enable cancer to grow. This breakthrough has made once-fatal forms of the disease manageable and transformed how cancer is treated. The OHSU Knight Cancer Institute is the only National Cancer Institute-designated Cancer Center between Sacramento and Seattle – an honor earned only by the nation's top cancer centers. It is headquarters for one of the National Cancer Institute's largest research collaboratives, SWOG, in addition to offering the latest treatments and technologies as well as hundreds of research studies and clinical trials.

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