Knight Diagnostic Laboratories’ expertise in genetics and molecular pathology join together in the diagnosis of inherited cancer syndromes. While most cancer is sporadic, 5-10% of all cancers are inherited. Syndromes may have either recessive or dominant inheritance. Oregon Health and Science University is a center of excellence for Fanconi anemia, a recessive inherited syndrome. Knight Diagnostic Laboratories has been providing comprehensive molecular analyses of the Fanconi genes and other disorders for many years. All inherited cancer syndrome testing is performed and interpreted as described for genetic rare disorders by American College of Medical Genetics.
Showing Results 1 to 10 of 23.

B and T-Cell Receptor (TCR) Gene Rearrangement, PCR

  • Test Code:
    5590
  • Department:
  • Test Synonyms:
    T-Cell Rearrangement Gene Rearrangement for T-cell lymphoma T-Cell Clonality T-Cell Receptor Gamma Clonality T-Cell Receptor Beta Clonality Immunoglobulin light chain clonality Kappa gene rearrangement Kappa gene clonality Gene rearrangements for B-cell lymphoma; B cell gene rearrangement for clonality
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B-Cell Gene Rearrangement

  • Test Code:
    4070
  • Department:
  • Test Synonyms:
    Immunoglobulin (IgH) Gene Rearrangement Immunoglobulin (IgH) Clonality Immunoglobulin light chain clonality Kappa gene rearrangement Kappa gene clonality Gene rearrangements for B-cell lymphoma; B cell gene rearrangement for clonality
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BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative)

  • Test Code:
    4020
  • Department:
  • Test Synonyms:
    Imatinib resistance mutation testing Tyrosine kinase inhibitor resistance mutation testing; ABL mutation testing for chronic myeloid leukemia T3151 Mutation
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BCR-ABL RNA PCR Quantitation for Leukemia

  • Test Code:
    4080
  • Department:
  • Test Synonyms:
    BCR-ABL RNA Philadelphia chromosome fusion transcript levels determination BCR-ABL PCR CML monitoring CML minimal residual disease
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CALRETICULIN (CALR) Gene Mutations in Myeloproliferative Neoplasms

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CEBPA Mutation Testing in Acute Myeloid Leukemia (AML)

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Engraftment (Chimerism) Analysis for Allogeneic Hematopoietic Stem Cell

  • Test Code:
    4380 (Donor Pre-Transplant) 4382 (Recipient Pre-Transplant) 4388 (Post Transplant Chimerism) 4390 (Sorted Cell Chimerism)
  • Department:
  • Test Synonyms:
    Pretransplant DNA storage Post-transplant DNA for engraftment study DNA from sorted cells for chimerism study
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Erythrocytosis Panel

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FLT3 Mutation Analysis

  • Test Code:
    4460
  • Department:
  • Test Synonyms:
    FMS-like tyrosine kinase 3 internal tandem duplication FLT3 D835 FLT3 ITD
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GeneTrails Hematologic Malignancies 76 Gene Panel

  • Test Code:
    4600
  • Department:
  • Test Synonyms:
    Heme Malignancies Panel Leukemia Panel AmpliSeq AML Panel Ion Torrent Next Gen Sequencing Heme Malignancies Panel Next Gen Sequencing Leukemia Panel ABL ATM ASXL1 BCL2 BCL6 BCOR BIRC3 BRAF CALR CARD11 CBL CBL-B CCND1 C79B CDKN2A CEBPA CREBBP CSF3R DNMT3A EP300 ETV6 EZH2 FAM5C FBXW7 FLT3 FOXO1 GNA13 GATA1 GATA2 HNRNPK HRAS IDH1 IDH2 ID3 IKZF1 IL7R JAK1 JAK2 JAK3 KDM6A/UTX KIT KRAS MEF2B MLL MLL2 MPL MYC MYD88 NOTCH1 NOTCH2 NPM1 NRAS PAX5 PHF6 PRDM1 PTEN PTPN11 (SHP2) RAD21 RUNX1 SETBP1 SF3B1 SMC1A SMC3 SOCS1 SRSF2 STAG2 STAT3 SUZ12 TCF3 TET2 TNFAIP3 TNFRSF14 TP53 U2AF35 (U2AF1) WT1 ZRSR2
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The Knight Cancer Institute at Oregon Health & Science University is a pioneer in the field of precision cancer medicine. The institute's director, Brian Druker, M.D., helped prove it was possible to shut down just the cells that enable cancer to grow. This breakthrough has made once-fatal forms of the disease manageable and transformed how cancer is treated. The OHSU Knight Cancer Institute is the only National Cancer Institute-designated Cancer Center between Sacramento and Seattle – an honor earned only by the nation's top cancer centers. It is headquarters for one of the National Cancer Institute's largest research collaboratives, SWOG, in addition to offering the latest treatments and technologies as well as hundreds of research studies and clinical trials.

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