The Hematologic Malignancy team at the Knight Diagnostic Laboratories performs diagnostic and clinically actionable tests developed at Oregon Health & Science University.  The department utilizes a variety of molecular platforms which allows testing to be developed using the most appropriate technology available for the application.  Testing includes quantitative real-time PCR, high resolution melting curve (HRM) analyses, Sanger sequencing, and Next Generation sequencing.
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Tests in Hematological Malignancies
Showing Results 1 to 10 of 31.

B-Cell IGH Gene Rearrangement

  • Test Code:
    4071
  • Department:
    Hematological Malignancies
  • Test Synonyms:
    Immunoglobulin (IgH) Gene Rearrangement • Immunoglobulin (IgH) Clonality • Immunoglobulin light chain clonality • Gene rearrangements for B-cell lymphoma • B cell gene rearrangement for clonality
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B-Cell IGK Gene Rearrangement

  • Test Code:
    4072
  • Department:
    Hematological Malignancies
  • Test Synonyms:
    Kappa gene rearrangement • Kappa gene clonality • Gene rearrangements for B-cell lymphoma • B cell gene rearrangement for clonality
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BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative)

  • Test Code:
    4020
  • Department:
    Hematological Malignancies
  • Test Synonyms:
    Imatinib resistance mutation testing • Tyrosine kinase inhibitor resistance mutation testing; • ABL mutation testing for chronic myeloid leukemia • T3151 Mutation
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BCR-ABL RNA PCR Quantitation for Leukemia

  • Test Code:
    4080
  • Department:
    Hematological Malignancies
  • Test Synonyms:
    BCR-ABL RNA • Philadelphia chromosome fusion transcript levels determination • BCR-ABL PCR • CML monitoring • CML minimal residual disease
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BTK Inhibitor Acquired Resistance Panel

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BTK, Exon 14, Sequencing

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CALRETICULIN (CALR) Gene Mutations in Myeloproliferative Neoplasms

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cKIT - AML

  • Test Code:
    4206
  • Department:
    Hematological Malignancies
  • Test Synonyms:
    KIT (cKIT) Mutation Screening for Acute Myelogenous Leukemia (exons 8 & 17)
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CXCR4 Mutation Testing

  • Test Code:
    4133
  • Department:
    Hematological Malignancies
  • Test Synonyms:
    Lymohoplasmacytic lymphoma • Waldenstroms • WM • LPL
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Engraftment (Chimerism) Analysis for Allogeneic Hematopoietic Stem Cell

  • Test Code:
    4380 (Donor Pre-Transplant) 4382 (Recipient Pre-Transplant) 4388 (Post-Transplant Chimerism) 4390 (Post-Transplant Sorted Cell Chimerism)
  • Department:
    Hematological Malignancies
  • Test Synonyms:
    Pretransplant DNA storage • Post-transplant DNA for engraftment study • DNA from sorted cells for chimerism study
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Innovations in Testing
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The Knight Cancer Institute at Oregon Health & Science University is a pioneer in the field of precision cancer medicine. The institute's director, Brian Druker, M.D., helped prove it was possible to shut down just the cells that enable cancer to grow. This breakthrough has made once-fatal forms of the disease manageable and transformed how cancer is treated. The OHSU Knight Cancer Institute is the only National Cancer Institute-designated Cancer Center between Sacramento and Seattle – an honor earned only by the nation's top cancer centers. It is headquarters for one of the National Cancer Institute's largest research collaboratives, SWOG, in addition to offering the latest treatments and technologies as well as hundreds of research studies and clinical trials.

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