Background:
The inherited cardiomyopathies comprise a group of genetically heterogeneous diseases, the most common of which are hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), and left ventricular non-compaction (LVNC). These disorders have an impact across all age groups. Overall, the prevalence of these disorders is estimated at approximately 1/500 (0.2%). This next-generation sequencing test is designed to detect mutations in the coding region of 33 genes associated with hypertrophic cardiomyopathy.
Reasons for Referral:
- Echocardiogram results suspicious for cardiomyopathy.
- Clinical presentation consistent with cardiomyopathy.
- Positive family history for cardiomyopathy (targeted testing is available if familial mutation is known).
- Carrier testing.
For detailed information and ordering instructions, please refer to Full Gene Analysis (1240). Genes may be added or removed from the list below if clinically indicated.
Hypertrophic Cardiomyopathy:
ACTC1, ACTN2, ANKRD1, CAV3, COX15, CSRP3, FXN, GAA, GLA, JPH2, LAMP2, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYLK2, MYOZ2, MYPN, NEXN, PLN, PRKAG2, PTPN11, RAF1, SCO2, SURF1, TCAP, TNNC1, TNNI3, TNNT2, TPM1, TTR, VCL
Methodology:
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Additional Info: