Background:
Lipid disorders comprise a group of heterogenic conditions often with overlapping clinical features such as abnormal levels of HDL, LDL, or triglycerides. High levels of HDL cholesterol in blood have been shown to atherogenic; these conditions include hypoalphalipoproteinemia and cholesteryl ester transferase deficiency. This next-generation sequencing test is designed to detect mutations in the coding region of 3 genes associated with high HDL levels.
Reasons for Referral:
- Abnormally high levels of HDL cholesterol.
- Clinical presentation consistent with a lipid disorder.
- Positive family history for High HDL (targeted testing is available if familial mutation is known).
- Carrier testing.
For detailed information and ordering instructions, please refer to Full Gene Analysis (1240). Genes may be added or removed from the list below if clinically indicated.
High HDL Panel (3 genes):
APOA1, CETP, SCARB1
Methodology:
Specimen Requirements:
Test Performed (Days):
Turn Around Time:
Shipment Sensitivity Requirements:
References:
Additional Info: