• Test Code:
    1340
  • Department:
    Molecular Genetics
  • Test Synonyms:
    Exon-centric microarray • Cardiomyopathy • Hypertrophic Cardiomyopathy • Dilated Cardiomyopathy • Noonan Syndrome • Hearing Loss • Autism • Inherited Cancer
  • CPT Code(s):
    81228
Background:

This focused microarray study will assess and report only the genetic regions (exons and proximal backbone) outlined and contained within each of our next generation sequencing (NGS) panels.  Gene contents of each panel are listed separately for each panel – please see our website for more details or contact our lab.  The name and ordering information for each panel is listed below. 

NOTE: a panel(s) must be selected for this test to be ordered. 

NGS panels with available exon-centric microarray testing (please see individual test information sheet or contact lab for gene content of each panel):

  1. Cardiomyopathy
  2. Hypertrophic Cardiomyopathy
  3. Dilated Cardiomyopathy
  4. Noonan Syndrome
  5. Hearing Loss
  6. Autism
  7. Inherited Cancer

Reasons for Referral:

  • Single pathogenic mutation detected in a gene with recessive inheritance
  • No mutation detected using a NGS panel offered through our lab

Methodology:

For this panel testing, the CytoSure Medical Research Exome Array (1 million elements) is used; this array is exon-specific, with 4,645 medically-relevant genes interrogated.  The majority of exons are covered by at least 4 oligonucleotide probes per exon, with average backbone spacing at 42Kb.  For the current testing strategy, only a fraction of the total genes on the array is assessed, as defined by the ordering provider.

Specimen Requirements:

Blood: EDTA or ACD (Solution A or B):

  • Adult: 5 mL
  • Child: 5 mL
  • Infant: 2-3 mL

A REQUISITION FORM MUST ACCOMPANY ALL SAMPLES.  Please include detailed clinical information, including ethnicity, clinical history, and family history.

Test Performed (Days):

Weekly

Turn Around Time:

8 weeks

Shipment Sensitivity Requirements:

  • Package and ship specimen to remain cold, but not frozen. 
  • Ship via overnight express, using the FedEx priority overnight label provided. 
  • Contact Client Services for shipping kits and instructions at (855) 535-1522.

References:

Additional Info:

 

Contact Us
Innovations in Testing
View All Tests

The Knight Cancer Institute at Oregon Health & Science University is a pioneer in the field of precision cancer medicine. The institute's director, Brian Druker, M.D., helped prove it was possible to shut down just the cells that enable cancer to grow. This breakthrough has made once-fatal forms of the disease manageable and transformed how cancer is treated. The OHSU Knight Cancer Institute is the only National Cancer Institute-designated Cancer Center between Sacramento and Seattle – an honor earned only by the nation's top cancer centers. It is headquarters for one of the National Cancer Institute's largest research collaboratives, SWOG, in addition to offering the latest treatments and technologies as well as hundreds of research studies and clinical trials.

Learn More