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Lipid disorders comprise a group of heterogenic conditions often with overlapping clinical features such as abnormal levels of HDL, LDL, or triglycerides. Clinical indications for dyslipidemia are low HDL cholesterol and elevated triglycerides and LDL cholesterol measured in serum. These conditions can lead to issues including coronary artery disease, stroke and peripheral artery disorders.   This next-generation sequencing test is designed to detect mutations in the coding regions within two genes associated with dyslipidemia.

Reasons for Referral:

  • Abnormal levels of HDL, LDL, or triglycerides.
  • Clinical presentation consistent with a lipid disorder.
  • Positive family history (targeted testing is available if familial mutation is known).
  • Carrier testing.
For detailed information and ordering instructions, please refer to Full Gene Analysis (1240). Genes may be added or removed from the list below if clinically indicated.

Dyslipidemia Panel 
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  1. Merck Manual http://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/lipid-disorders/dyslipidemia
  2. Nora L. Nock and Aiswarya L.P. Chandran Pillai (2012). Dyslipidemia: Genetics and Role in the Metabolic Syndrome
  3. Dyslipidemia - From Prevention to Treatment, Prof. Roya Kelishadi (Ed.), ISBN: 978-953-307-904-2, InTech

Additional Info:

The Knight Cancer Institute at Oregon Health & Science University is a pioneer in the field of precision cancer medicine. The institute's director, Brian Druker, M.D., helped prove it was possible to shut down just the cells that enable cancer to grow. This breakthrough has made once-fatal forms of the disease manageable and transformed how cancer is treated. The OHSU Knight Cancer Institute is the only National Cancer Institute-designated Cancer Center between Sacramento and Seattle – an honor earned only by the nation's top cancer centers. It is headquarters for one of the National Cancer Institute's largest research collaboratives, SWOG, in addition to offering the latest treatments and technologies as well as hundreds of research studies and clinical trials.

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