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The inherited arrhythmias comprise a group of genetically heterogeneous diseases Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), Long QT Syndrome, and Short QT Syndrome.  These disorders have an impact across all age groups. 

Brugada syndrome is a cardiac conduction abnormality that can lead to ventricular arrhythmia, syncope, seizures, difficulty breathing, or sudden death.  The prevalence of Brugada syndrome is currently unknown. This next-generation sequencing test is designed to detect mutations in the coding region of 9 genes associated with Brugada Syndrome.

Reasons for Referral:

  • Presence of arrhythmia.
  • Clinical presentation consistent with Brugada syndrome.
  • Positive family history for arrhythmia (targeted testing is available if familial mutation is known).
  • Carrier testing.
For detailed information and ordering instructions, please refer to Full Gene Analysis (1240). Genes may be added or removed from the list below if clinically indicated.

The 9 Brugada associated genes are listed below:


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  1. GeneReviews:Brugada et al., 2014, http://www.ncbi.nlm.nih.gov/books/NBK1517/
  2. Genetics Home Reference: http://ghr.nlm.nih.gov/condition/brugada-syndrome

Additional Info:

The Knight Cancer Institute at Oregon Health & Science University is a pioneer in the field of precision cancer medicine. The institute's director, Brian Druker, M.D., helped prove it was possible to shut down just the cells that enable cancer to grow. This breakthrough has made once-fatal forms of the disease manageable and transformed how cancer is treated. The OHSU Knight Cancer Institute is the only National Cancer Institute-designated Cancer Center between Sacramento and Seattle – an honor earned only by the nation's top cancer centers. It is headquarters for one of the National Cancer Institute's largest research collaboratives, SWOG, in addition to offering the latest treatments and technologies as well as hundreds of research studies and clinical trials.

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