• Test Code:
  • Department:
  • Test Synonyms:
    Prenatal FISHAneuploidy ScreenI-FISH
  • CPT Code(s):

AneuVysion, an FDA-approved fluorescent in situ hybridization (FISH) technology, is a set of probes used on uncultured amniocytes or chorionic villi to rapidly detect trisomies 13, 18, and 21  and sex chromosome aneuploidy.  Together these conditions account for a significant proportion of all chromosome abnormalities identified at the time of amniocentesis and the majority of clinically significant chromosomal abnormalities detected in live-born infants. 

The AneuVysion FISH screen is particularly useful when there is high suspicion for chromosome aneuploidy involving the targeted chromosomes based on fetal anomalies detected by ultrasonography.   Results are rapidly available, within 24-72 hours after the amniotic fluid is received in the laboratory.  This FISH test is considered preliminary and should be confirmed on chromosome analysis or chromosomal microarray.


Slides are prepared per standard protocols and 100 interphase cells are scored for each probe under fluorescence microscopy.

Specimen Requirements:

Amniotic Fluid:  18-24 mL.

  • Discard or separately collect first one or two mL fluid (can be used for AFP).
  • If fluid is bloody, add 0.5 mL sodium heparin (1000 units/mL) to each 10 mL of fluid and mix well.
  • Keep at room temperature.
  • Prior to sending a sample, please call Client Services for shipping kits and instructions: (855) 535-1522 or (503) 494-5400.

A REQUISITION FORM MUST ACCOMPANY ALL SAMPLES.  Please include detailed clinical information, including ethnicity, clinical history, and family history.

Test Performed (Days):

Mon - Sat

Turn Around Time:

≤3 days: Contact Lab at 855-KDL-1LAB (535-1522) - Time varies depending on number and type of tests performed.

Shipment Sensitivity Requirements:

  • Keep the specimen at room temperature during transit.
  • Do not use the cold pack provided in the KDL shipping kit.
  • Ship the specimen overnight express, using the FedEx priority overnight label provided. 
  • The specimen must arrive at the lab no more than 24 hours after collection.
  • Contact Client Services at (855) 535-1522 for shipping kits and instructions.


Additional Info:

The Knight Cancer Institute at Oregon Health & Science University is a pioneer in the field of precision cancer medicine. The institute's director, Brian Druker, M.D., helped prove it was possible to shut down just the cells that enable cancer to grow. This breakthrough has made once-fatal forms of the disease manageable and transformed how cancer is treated. The OHSU Knight Cancer Institute is the only National Cancer Institute-designated Cancer Center between Sacramento and Seattle – an honor earned only by the nation's top cancer centers. It is headquarters for one of the National Cancer Institute's largest research collaboratives, SWOG, in addition to offering the latest treatments and technologies as well as hundreds of research studies and clinical trials.

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