Background:
The inherited arrhythmias comprise a group of genetically heterogeneous diseases Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), Long QT Syndrome, and Short QT Syndrome. These disorders have an impact across all age groups. This next-generation sequencing panel is a comprehensive test which targets the coding region of 23 genes associated with arrhythmia.
Reasons for Referral:
- Presence of arrhythmia.
- Positive family history for arrhythmia (targeted testing is available if familial mutation is known).
- Carrier testing.
For detailed information and ordering instructions, please refer to Full Gene Analysis (1240). Genes may be added or removed from the list below if clinically indicated.
Comprehensive Arrhythmias (23 genes):
AKAP9, ANK2, CACNA1C, CACNB2, CALM1, CASQ2, CAV3, GPD1L, HCN4, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNQ1, RYR2, SCN1B, SCN3B, SCN4B, SCN5A, SNTA1, TRDN, TRPM4
Methodology:
Specimen Requirements:
Test Performed (Days):
Turn Around Time:
Shipment Sensitivity Requirements:
References:
- GeneReviews: Alders et al., 2015, http://www.ncbi.nlm.nih.gov/books/NBK1129/
- Genetics Home Reference: http://ghr.nlm.nih.gov/glossary=longqtsyndrome
Additional Info: