The Histopathology Shared Resource (HSR) is a College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA) accredited core facility that provides investigators with histology services critical for the progress of biomedical research.  Additionally, we provide investigators with consultation and education in regard to best use of histopathology services.

Services
The HSR provides an array of pathology related services in support of basic, translational, and clinical research.

Histology
    1. Tissue fixation, processing and embedding
    2. Tissue sectioning
    3. Cryostat sections (frozen tissues)
    4. Sectioning for RT-PCR or other molecular studies
    5. H&E staining
    6. Decalcification of bone and cartilage
    7. Special stains, e.g., Trichrome, Elastin, Iron, Reticulin, Giemsa, Etc.


HSR staff can advise researchers on tissue preparation, preservation and handling to ensure the highest quality of results. Our staff have years of experience handling samples from small animals ensuring that tissues are properly embedded and precisely sectioned as requested. 

Immunohistochemistry
The Histopathology Shared Resource provides Immunohistochemistry services which include:

    1. Immunostaining of established antibodies
    2. ​Optimization of new antibodies
    3. Double staining for brightfield
    4. TUNEL
    5. ​Multiple Chromogens, e.g.: DAB, Fast Red, AP Blue, AP Green
    6. Multiple Counterstains, e.g.: Hematoxylin, Methyl-Green
    7. High-Throughput Automated IHC staining on the Ventana BenchMark XT and BOND RX platforms


Pathology consultative services
HSR can provide advice on histology, biomarker studies, research protocols, safety issues and grants applications.

List of Optimized Antibodies by HSR
The Histopathology Shared Resource has performed various IHC Stains:


Questions?
Contact us for any additional information regarding our IHC Services.

503-494-9631

The Knight Cancer Institute at Oregon Health & Science University is a pioneer in the field of precision cancer medicine. The institute's director, Brian Druker, M.D., helped prove it was possible to shut down just the cells that enable cancer to grow. This breakthrough has made once-fatal forms of the disease manageable and transformed how cancer is treated. The OHSU Knight Cancer Institute is the only National Cancer Institute-designated Cancer Center between Sacramento and Seattle – an honor earned only by the nation's top cancer centers. It is headquarters for one of the National Cancer Institute's largest research collaboratives, SWOG, in addition to offering the latest treatments and technologies as well as hundreds of research studies and clinical trials.

Learn More